Monday, February 18, 2013

Rise of Islamists frays strategic UAE-Egyptian relations

DUBAI (Reuters) - Days before his overthrow, Egyptian President Hosni Mubarak received a senior visitor from the United Arab Emirates (UAE), one of several Gulf monarchies long supportive of the most Arab populous country and its veteran strongman.

What transpired between Mubarak and Foreign Minister Sheikh Abdullah bin Zayed al-Nahayan is not known, beyond the fact that a letter from UAE ruler Sheikh Khalifa bin Zayed al-Nahayan was delivered.

But the significance of the February 8, 2011 visit was clear: It was a gesture of understanding and concern for a longtime friend who had been a trusted diplomatic ally for most Gulf Arabs, not least in their confrontation with non-Arab Iran.

Fast forward to 2013 and the picture is starkly different.

The UAE-Egyptian relationship has been strained by the regional spread of Islamist influence - Egypt now has an elected Islamist president - with implications not only for the two protagonists but all Arab states hit by the uprisings against dictators and dynasties that began two years ago.

Poorer, densely populated Arab states like Egypt often look to Gulf states for investment and financing, as well as overseas work for their nationals, a need ever more acute with rulers under unprecedented pressure to produce jobs and services.

The UAE, home to around 380,000 Egyptian expatriates and a major investor in Egypt, pledged $3 billion of aid to Cairo in 2011. But the funds have not yet been transferred, an Egyptian source familiar with the matter told Reuters, mainly due to the political instability in post-revolution Egypt.

A break in relations between the Arab political heavyweight and the Gulf financial powerhouse would be unthinkable. But the unfamiliar chill in their dealings reflects an increasingly complicated relationship between these two groups of countries.

Gulf states historically have sent aid and investment to less moneyed fellow Arabs, and in return have received diplomatic support and sometimes military protection.

The UAE-Egypt spat "does have a huge bearing on the success of the Arab transitions", said Jane Kinninmont of the British think tank Chatham House.

HUGE ECONOMIC NEEDS

"Here you have a number of countries which are going through transitions but which have huge economic needs. The obvious place for them to look is the wealthy Gulf Arab countries."

Arab countries received 62 percent of all Gulf aid from 1970 to 2008, according to a study by researchers Bessma Momani and Crystal Ennis in the Cambridge Review of International Affairs.

For its part, the UAE needs to tread a careful line, analysts say.

Aggravating Egypt's Muslim Brotherhood could also affect UAE relations with other countries, like Syria, where Islamists are playing a major role in the revolt against President Bashar al-Assad.

And irking Egypt's new rulers could also push Cairo closer to Shi'ite Iran, arch-adversary of the Gulf Arabs.

Gulf Sunni Muslim rulers fear that, despite being a Sunni group itself, the Brotherhood is soft on Iran, unlike Mubarak.

"The Emirates recognise that Egypt's centrality in Arab affairs is an important counter to Iran," said Frederic Wehrey, Middle East program senior associate at Carnegie Endowment for International Peace think-tank.

Gulf Arab states need a prosperous Egypt for a host of reasons, not least to protect their own investments.

But history shows that financial help from the region sometimes reflects shifts in the diplomatic climate - even if governments insist their assistance is not political.

For example Jordan's ties with Gulf were hurt in 1990 when it refused to join an alliance against Iraq after it invaded Kuwait. Many Palestinians and Jordanians lost jobs in the Gulf where they enjoyed welfare state benefits as expatriate workers.

There are implications, too, for Gulf Arab states. Most saw Mubarak's fall as the result of a U.S. decision to cast adrift an erstwhile ally and common adversary of Iran, rather than as an acceptance of an unstoppable revolution.

Crucially, Gulf Arab rulers alarmed by Mubarak's ouster were further disconcerted by the subsequent ascent to power of the Muslim Brotherhood, Mubarak's sworn foe and a group once cited in a U.S. diplomatic cable as the UAE's "mortal enemy".

If Washington was ready to deal with the Muslim Brotherhood in Cairo, could it do the same in the Gulf, if a new democratic dispensation swept away the region's tradition of princely rule?

ANXIETY

There is no shortage of evidence of UAE worries about the reach of Islamists. On January 27 the UAE announced 94 of its citizens would go on trial on charges of seeking to seize power, accusing them of being in communication with the Brotherhood.

Many are believed to be members of al-Islah, an Islamist group suspected of links to the Brotherhood, a movement founded in Egypt in 1928 and which is banned in the Gulf Arab state. Islah says it has no connection to the global Brotherhood.

Some analysts say the arrests are meant to send a message that Islamist activities will not be tolerated, rather than reflecting a belief they pose a significant security threat.

"The UAE has a rule: zero tolerance for political organisations of any sort whether Islamists or non-Islamists, and these guys (Emiratis and Egyptians) broke the law. Pure and simple," UAE political scientist Abdelkhaleq Abdullah said.

But the UAE has continued to strike a firm tone in public.

In October, Sheikh Abdullah, the foreign minister, said: "The Muslim Brotherhood does not believe in the nation state. It does not believe in the sovereignty of the state."

An Emirati source close to the government said the minister's comments were directed at the Brotherhood, not Egypt, and the UAE saw the bilateral relationship as a strategic one.

On January 1, a local newspaper reported that the UAE had also arrested 11 Egyptians on suspicion of training Islamists in how to overthrow governments.

The Brotherhood replied by saying the 11 were wrongfully arrested. Local media in the UAE said the Gulf Arab states had rejected a subsequent request by Cairo to free the detainees.

For its part, the Brotherhood has sought to reassure Gulf Arabs it has no plan to push for political change beyond Egypt's borders. Egyptian President Mohamed Mursi has said there is no plan to "export the revolution" - comments welcomed by the UAE.

Both Egypt and the UAE publicly assert that they have a special relationship. After all, Sheikh Abdullah had a meeting with Mursi, whose roots are in the Brotherhood, in Egypt in September 2012 and delivered an invitation for him to visit the UAE. A response is awaited.

PERIODS OF STRAIN

And yet the discordant tone will stir questions over Gulf Arab willingness to make good on promises of support to Egypt, which desperately needs funds to avert financial crisis.

While Gulf Arabs have pledged large sums to Egypt, helping stabilise its currency, they are motivated by their own interests, Richard LeBaron, a former U.S. ambassador to Kuwait, wrote in a study for the Atlantic Council think-tank.

He said most Gulf Arab states, wary of the Brotherhood, had adopted a "wait and see" attitude toward new leaders in Egypt and Tunisia before committing significant additional funds and seemed not to sense any urgency in making such decisions.

Carnegie Endowment's Wehrey wrote that while UAE-Egypt ties could face more turbulence, matters could be resolved due to shared interests including a need to counter Iranian influence and the Brotherhood's need for Gulf investment.

"A key first step is for both sides to avoid strident and provocative statements that fuel the rancour that currently afflicts the relationship," he said.

Source: http://news.yahoo.com/rise-islamists-frays-strategic-uae-egyptian-relations-173037390.html

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'Activating' RNA takes DNA on a loop through time and space

Feb. 17, 2013 ? Long segments of RNA -- encoded in our DNA but not translated into protein -- are key to physically manipulating DNA in order to activate certain genes. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

In an online article of the journal Nature, a team of scientists led by Wistar's Ramin Shiekhattar, Ph.D., detail the mechanism by which long non-coding RNA-activators promote gene expression. They show how these RNA molecules help proteins in the cell to create a loop of DNA in order to open up genes for transcription. Their experiments have also described how particular ncRNA-a molecules are related to FG syndrome, a genetic disease linked to severe neurological and physical deficits.

"These ncRNA-activators can activate specific genes by working with large protein complexes, filling in a big piece of the puzzle," said Shiekhattar, Herbert Kean, M.D., Family Professor and senior author of the study. "Our DNA encodes thousands of these ncRNA-activators, each with a role in timing the expression of a specific gene. As we learn more about non-coding RNA, I believe we will have a profoundly better understanding of how our genes function."

Their findings also provide a plausible mechanism of how locations along chromosomes, classically known as "enhancer" elements, can influence the expression ("reading") of genes located 5,000 to 100,000 base pairs ("letters") of DNA away. According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. "There is an abundance of evidence to indicate that enhancers are critical components of transcription during embryonic development and disease process," Shiekhattar said.

"Non-coding RNAs are probably one of the earliest molecules that determine spatial and temporal gene expression in a developing embryo," Shiekhattar said. "These enhancers can help turn genes on and off as a growing embryo would need, but as we have seen in other genetic mechanisms of embryonic development, they can lead to cancer if they are switched on inappropriately in adult cells."

In the classic "central dogma" of biology, chromosomal DNA is transcribed into RNA, which is then translated by the cell into proteins. In recent years, however, scientists have found that not all transcribed RNA molecules become translated into proteins. In fact, studies have shown that large portions of the genome are transcribed into RNA that serve tasks other than functioning as blueprints for proteins.

In 2010, the Shiekhattar lab first published the discovery of these ncRNA enhancer molecules in the journal Cell (2010 Oct 1;143(1):46-58), and theorized on their role as "enhancers" of gene expression. Since then, laboratories around the world have published and linked ncRNAs not only to transcriptional enhancers but also to certain diseases, including some cancers.

To discover how such enhancer-like RNAs function, the Shiekhatter laboratory deleted candidate molecules with known roles in activating gene expression, and assessed if they were related to RNA-dependent activation. They found that depleting components of the protein complex known as Mediator specifically and potently diminished the ability of ncRNA-a to start the process of transcribing a gene into RNA. Further, they found that these activating ncRNAs can attach to Mediator at multiple locations within the Mediator protein complex, and Mediator itself can interact with the enhancer element site on DNA that encodes these activating ncRNAs. Their results also determined how mutations in a protein that makes up the Mediator complex, called MED12, drastically diminishes Mediator's ability to associate with activating ncRNAs.

Mutations in the MED12 protein are a marker for FG syndrome (also know as Opitz-Kaveggia syndrome), a rare genetic disorder that leads to abnormalities throughout the body and varying degrees of physical and neurological problems. "This clearly shows how activating ncRNAs can influence disease development, an idea that has been gaining evidence in the scientific literature," Shiekhattar said.

To confirm that ncRNA-a works with Mediator to form a loop in DNA, the researchers used a technique called chromosome conformation capture (3C) to gain a better understanding of the three-dimensional structure of chromosomes. Their results show how Mediator gets a foothold of sorts on the portion of DNA that encodes the ncRNA-a, and twists the DNA to form a loop.

"The looping mechanism serves to physically bring together a distant enhancer element with the start site of the targeted gene, allowing Mediator to recruit the proteins responsible for reading the gene to the location," Shiekhattar said. "It is at least one answer to how these classical enhancer elements function while being physically distant from their target genes."

The Philadelphia Inquirer discussed these findings with Shiekhattar, and he reveals why he refers to them views ncRNA-activators as the "dark matter of biology."

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Story Source:

The above story is reprinted from materials provided by The Wistar Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Fan Lai, Ulf A. Orom, Matteo Cesaroni, Malte Beringer, Dylan J. Taatjes, Gerd A. Blobel, Ramin Shiekhattar. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature, 2013; DOI: 10.1038/nature11884

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/lM5a2W4vYcE/130217134240.htm

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At UCI, iPad has helped turn the page on med-school teaching: The first medical-school class to be given textbook-loaded tablets has posted significant test-score improvements; applications have surged.

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How-To/Tutorial
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  • "How To Use Mailbox, The New Email App For iPhone Everyone Is Talking About"?Business Insider?2/16
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Tips
  • "Ask Rick: how can I get emails on my iPad? A reader is having trouble picking up Virgin emails on his iPad."?Telegraph?2/16
  • "Know Who is Calling Even if iPhone is Silent with Custom Vibration Alerts"?OS X Daily?2/15
  • "Low Latency No. 51: Smartwatch epiphany"?CNET News [cartoon]?2/15
  • "More than five family devices sharing a single iTunes account Article"?iLounge?2/15
  • "Added features when using Stocks app in landscape mode"?Mac OS X Hints?2/15
Source: http://www.macsurfer.com/redirr.php?u=763162

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California Head Coach Mike Montgomery Angrily Shoves Bears Star Allen Crabbe

Monday, February 18, 2013 12:24 am

Tyler Moorehead - ND Campus Rep

Looks like California Bears head basketball coach Mike Montgomery is a big fan of Bobby Knight.

Sunday night, Montgomery?s temper began to flare as his Bears were playing poorly against the USC Trojans. Upset and trying to get the attention of his star, Allen Crabbe, Montgomery furiously shoved him in his chest. Initially Crabbe was upset and went back to the locker room ? here?s the video:

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However, it should be noted that even if Crabbe was upset at first, the shove did serve as quite a wake-up call. Crabbe scored 14 points after the incident and the Bears rallied to beat the Trojans.

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This is sure to be the talk of ESPN tomorrow ? was Montgomery?s reaction acceptable or too much?

Source: http://collegespun.com/buzzworthy/california-head-coach-mike-montgomery-angrily-shoves-bears-star-allen-crabbe

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